Cook flashed the rust of a run-first approach in Week 1, contributing to Buffalo's 108-yard rushing effort with a heavy workload that could rebound as the Bills rework the run game around Allen's explosiveness.

Cook logged a TD on the ground and added a 51-yard reception, highlighting his explosiveness as Buffalo’s complementary back in a potent offensive attack.

Cook anchors Buffalo’s balanced attack, providing a reliable ground game to pair with Allen’s aerial skills. His involvement in both rushing and receiving duties offers steady PPR upside, particularly with Bass out, where Buffalo may lean on efficient short-yardage plays and catching out of the backfield.

Cook anchors Buffalo’s ground game with a 54.5 rushing yards line and 16 rushing TDs from 2024, offering solid running back value in a run-friendly Bills offense. His involvement in both the run and pass game provides a reliable floor with ceiling upside, especially in a Week 1 clash against Baltimore’s defense.

James Cook appeared to be dealing with an injury during Week 1 against Baltimore, exiting briefly to the medical tent before returning to action. His health status remains a focal point, as any limitation could elevate Ray Davis or Ty Johnson into more prominent roles. Cook’s involvement, even if limited, will heavily influence Buffalo’s ground game and Allen’s offensive workload in a high-stakes Week 1.